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診療と新薬 2020;57(11):961-969

CGRPの関与を含めた片頭痛病態の多面性について

東京歯科大学市川総合病院

Shinryo to Shinyaku (Med Cons New-Remed)2020;57(11):961-969

診療と新薬 2020;57(11):961-969

CGRPの関与を含めた片頭痛病態の多面性について

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診療と新薬 2020;57(11):971-978

Tosufloxacinの小児用キノロンとしての発売10年を振り返って

1)国立がん研究センター,2)富士フイルム富山化学株式会社,3)川崎医科大学

Shinryo to Shinyaku (Med Cons New-Remed)2020;57(11):971-978

Looking Back on the 10 Years Since the Launch of Tosufloxacin as a Pediatric Quinolone

1)National Cancer Center,2)FUJIFILM Toyama Chemical Co., Ltd. ,3)Kawasaki Medical School

診療と新薬 2020;57(11):971-978

Tosufloxacinの小児用キノロンとしての発売10年を振り返って

Shinryo to Shinyaku (Med Cons New-Remed)2020;57(11):971-978

Looking Back on the 10 Years Since the Launch of Tosufloxacin as a Pediatric Quinolone

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診療と新薬 2020;57(11):979-983

Shinryo to Shinyaku (Med Cons New-Remed)2020;57(11):979-983

Effects of Saccharomyces cerevisiae NK-1 in Improving the Intestinal Environment and Quality of Sleep: A Randomized, Double-blind, Crossover Study

1)Nikkenkyo Service Corporation,2)Tokyo Center Clinic,3)Faculty of Health Sciences for Welfare, Department of Nutritional Sciences for Well-being, Kansai University of Welfare Sciences

診療と新薬 2020;57(11):979-983

Shinryo to Shinyaku (Med Cons New-Remed)2020;57(11):979-983

Effects of Saccharomyces cerevisiae NK-1 in Improving the Intestinal Environment and Quality of Sleep: A Randomized, Double-blind, Crossover Study

1)Nikkenkyo Service Corporation,2)Tokyo Center Clinic,3)Faculty of Health Sciences for Welfare, Department of Nutritional Sciences for Well-being, Kansai University of Welfare Sciences

Background: Saccharomyces cerevisiae NK-1 is a simple, single-celled organism and is a yeast used for industrial and pharmaceutical purposes in the field of genetics and medicine. Yeast has intestinal regulating properties. Hence, the current study aimed to investigate whether Saccharomyces cerevisiae NK-1 can promote changes in the intestinal environment and sleep-related quality of life.
Methods: This was a randomized, double-blind, crossover study. Healthy men and women ingested a stick containing 10 billion Saccharomyces cerevisiae NK-1 or a placebo stick without Saccharomyces cerevisiae NK-1 three times a day for 4 weeks. Then, the proportion of intestinal flora was evaluated using the terminal restriction fragment length polymorphism methods, and quality of sleep was assessed with the Obstructive Sleep Apnea (OSA) questionnaire before and after ingestion. This study was registered in the UMIN Clinical Trials Registry prior to the study (UMIN-ID: UMIN000025190).
Results: The number of Bifidobacteria was significantly higher in the Saccharomyces cerevisiae NK-1 powder group than in the placebo group. Based on the OSA questionnaire findings, there were significant improvements in sleepiness and fatigue upon waking up in the Saccharomyces cerevisiae NK-1 powder group compared with the placebo group.
Conclusion: Saccharomyces cerevisiae NK-1 improved the intestinal environment by increasing the number of Bifidobacteria and sleepiness and fatigue upon waking up.

Key Words: S accharomyces cerevisiae NK-1, Bifidobacterium, OSA Sleep Questionnaire, Randomized, Double-blind Study

Shinryo to Shinyaku (Med Cons New-Remed)2020;57(11):979-983

Effects of Saccharomyces cerevisiae NK-1 in Improving the Intestinal Environment and Quality of Sleep: A Randomized, Double-blind, Crossover Study

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診療と新薬 2020;57(11):985-989

メイク落とし(クレンジングバーム)による目尻のシワ改善効果:ハーフフェイス法での4週間塗布試験による検討

1)株式会社ママコスメ,2)国立中央大学(台湾)

Shinryo to Shinyaku (Med Cons New-Remed)2020;57(11):985-989

Wrinkle Improvement Effect by Application of Warm Cray Cleansing (MMC CLEANSING BALM): Examination by Four Weeks Application Test by Half Face Method

1)Mamacosme Co., Ltd. ,2)National Central University

診療と新薬 2020;57(11):985-989

メイク落とし(クレンジングバーム)による目尻のシワ改善効果:ハーフフェイス法での4週間塗布試験による検討

Shinryo to Shinyaku (Med Cons New-Remed)2020;57(11):985-989

Wrinkle Improvement Effect by Application of Warm Cray Cleansing (MMC CLEANSING BALM): Examination by Four Weeks Application Test by Half Face Method

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